Seroquel is a drug often prescribed to patients with schizophrenia. The drug is sometimes used in the treatment of other mental health conditions, too, including bipolar disorder, for example. Individuals who take the medication may be at risk of developing abusive behavior. Understanding how Quetiapine metabolism works is essential for people who want to stop the use of Quetiapine. The chemicals in the drug may remain in one’s body for some time. By understanding Seroquel half-life, a person can know when the chemicals will be out of their body.

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So, how does Seroquel work, and what does it do? Does it show up on a drug test? And how long does Seroquel stay in your system?

Seroquel Mechanism of Action

Quetiapine is classified as an antipsychotic medicine. The resulting calming activity from the drug administration is believed to be down to the combination of antagonism at specific brain receptors. These include the 5HT2A receptors in the frontal cortex and D2 receptors in the mesolimbic pathway. These effects become dangerously increased when one overdoses on the medication.

How Does Seroquel Work For Mental Diseases?

Concerning the treatment of schizophrenia, it is believed that antipsychotics such as Quetiapine work to reduce all symptoms of this condition – negative and positive. They do so through the modulation of central serotonergic and dopaminergic activity in the brain. The activity in the D2 receptors suppresses the positive symptoms of the condition, while the activity in the 5HT2A receptors suppresses the negative symptoms.


Standard drug tests are not designed to detect Quetiapine. They can detect illicit substances or some prescription medications, like opioids. However, different other types of tests may be performed to detect the presence of Seroquel in a patient’s body. Some parts of one’s body may have remaining drug compounds for an extended period compared to other parts. Thus, it is important to differentiate between blood, urine, hair, and even saliva.

How Long Does Seroquel Stay In Your Blood and Urine?

It is generally thought that Seroquel will leave the system entirely within 48 hours. In one study about the detection of Quetiapine in a person’s blood, urine, and hair samples, the initial test was done in 43 hours following the drug administration. The researchers describe that traces of Quetiapine were found in both blood and urine samples.

This was within the 48 hours during which the drug is metabolized by the body. This period already exceeded the Quetiapine half-life, which explained the low concentration of the chemicals detected in urine and blood samples.

How Long Does Seroquel Stay In Your Hair Follicle?

At six months following the drug administration, traces of its active chemicals were still detectable in the patient’s hair samples. Thus, Seroquel does seem to remain active in hair follicles and in hair itself for a much more significant period compared to urine and blood samples.

Clearing Quetiapine From The System

When it comes to detoxing from the drug, it’s not advised to quit it cold-turkey. It will lead to Quetiapine withdrawal, and to make it easier, the dose should be tapered off gradually.

The person should also have a thorough understanding of Quetiapine warnings and consider the dosage – high doses lead to more serious adverse effects and causes the drug to remain active for longer. Speaking about such a side effect as Seroquel weight gain, it is not dose-dependent. So, even with a low dose, a patient can experience this side effect.

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While one is tapering off the drug, withdrawal may still appear. It is advisable to undergo medical detoxification to manage it faster and more effectively. If one feels unable to function daily without this drug, they may be addicted to Seroquel. This condition may lead to irreversible health damage and needs to be observed by addiction treatment experts. Help from a rehabilitation center should be admitted to begin a healthy and addiction-free life.

Page Sources

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