Drug synopsis & main distinctions | conditions treated | Efficacy | insurance coverage and also cost comparison | Side effects | medicine interactions | Warnings | FAQ

Tylenol #3 (acetaminophen/codeine) and also Percocet (acetaminophen/oxycodone) room two various opioid pain relievers. Both prescription medicine contain a combination of acetaminophen and also an opioid medication. Acetaminophen is a non-opioid analgesic that’s commonly found as an over-the-counter pain reliever. The addition of an opioid makes Tylenol #3 and Percocet potent pains medicines.

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Opioids like codeine and also oxycodone work by binding to mu-opioid receptors in the brain, which pat a duty in the emotion of pain throughout the body. In addition, through binding to these receptors, opioids block pain signals throughout the central nervous mechanism (CNS). Tylenol #3 and also Percocet come in pill forms, and they room meant to be supplied for short-lived pain since of their potential because that abuse and dependence.

While this opioid ache relievers have comparable ingredients and also purposes, there are some differences to note in between the two.

What are the key differences between Tylenol 3 vs. Percocet?

The main difference in between Tylenol #3 and Percocet is that Percocet is a much more potent prescription opioid. Tylenol #3 has codeine, i beg your pardon is weaker 보다 the benchmark opioid, morphine. In contrast, Percocet consists of oxycodone, an opioid that’s almost two times more potent than morphine.

Tylenol #3 (Tylenol #3 details) is a Schedule III or V drug with a lower potential for abuse than various other opioids. Low doses that codeine can sometimes be purchased over the counter for mild pains or cough. However, there is tho a threat of overdose if that is not taken as prescribed. Tylenol #3 comes in 300-30 mg tablets.

Because (Percocet details) that is a Schedule II drug, Percocet has actually a higher potential because that abuse compared to Tylenol #3. Percocet must only it is in taken once other pain relief alternatives have failed. Otherwise, the is regularly prescribed at low doses for pain. Percocet comes in 325-2.5 mg, 325-5 mg, 325-7.5 mg, 325-10 mg tablets.

Main differences in between Tylenol 3 vs. Percocet
Tylenol 3Percocet
Drug classOpioidsOpioid and also analgesic combinationOpioidsOpioid and also analgesic combination
Brand/generic statusBrand and also generic variation availableBrand and generic version available
What is the generic name?Acetaminophen/CodeineAcetaminophen/Oxycodone
What form(s) does the drug come in?Oral tabletOral tablet
What is the conventional dosage?One tablet computer (300 mg acetaminophen/30 mg codeine) every four hours as needed. Best of 4000 mg of paracetamol per day.

Dosage is individualized based upon severity of pain.

One to two tablets (2.5 come 10 mg that oxycodone) every four to six hrs as needed. Maximum of 4000 mg of acetaminophen per day.

Dosage is individualized based upon severity of pain.

How lengthy is the typical treatment?Short-term treatment, as directed by a medical care providerShort-term treatment, together directed through a medical care provider
Who typically uses the medication?AdultsAdults

Conditions cure by Tylenol 3 vs. Percocet

Tylenol #3 is FDA-approved to treat mild come moderate pain. The is regularly prescribed to relieve pain after particular injuries or dental procedures. For example, after a wisdom tooth extraction, Tylenol #3 may be provided for pains management.

Percocet is FDA authorized to treat moderate to major pain. Favor Tylenol #3, that can also be supplied to relieve pain after ~ injuries and also surgeries. Another common usage for opioids choose Percocet has cancer and chronic pain relief.

ConditionTylenol 3Percocet
Pain severe enough to need the require of one opioid analgesicYesYes

Is Tylenol 3 vs. Percocet more effective?

Tylenol #3 and Percocet are often prescribed because that pain the is not regulated with over-the-counter pains relievers favor non-steroidal anti-inflammatory drugs (NSAIDs). They’re both reliable treatment options depending on the type and severity of pain being treated. Professional medical advice need to be consulted top top the ideal opioid analgesic for details situations.

In one systematic evaluation of opioids for chronic noncancer pain, codeine to be classified as a weak opioid, and oxycodone to be classified as a solid opioid. Oxycodone, found in Percocet, was discovered to it is in significantly an ext effective than other drugs, such together naproxen, for chronic ache relief. ~ above the other hand, codeine was discovered to be as efficient as NSAIDs because that chronic pain relief.


One clinical trial to compare Tylenol #3 and also Percocet discovered that both opioid drugs are comparable in effectiveness. The study, which included 240 subjects, concluded that Tylenol #3 may be a reasonable alternate to “stronger” opioids because that acute pain in the eight or legs. Next effects and also patient-reported satisfaction were similar in both study groups.

The efficiency of an opioid analgesic may depend ~ above the severity the pain, dosing, and other therapies being used. This compare is because that informational objectives only. Always seek professional medical advice for the most efficient treatment alternatives for pain.

Coverage and cost compare of Tylenol 3 vs. Percocet

Tylenol #3 is accessible as a generic medicine that’s covered by many Medicare and insurance plans. Because that 20 share Tylenol #3 tablets, the typical cash price is approximately $18. V a ubraintv-jp.com Tylenol #3 coupon, the price may be lowered to roughly $8. Compare the cash price the this medication through your insurance copay and also your price v a discount card.

Percocet is widely obtainable as a generic medication. Share Percocet is regularly covered through Medicare and also insurance plans. The common cash price that Percocet tablet computers is around $22. However, this price deserve to be decreased by making use of a ubraintv-jp.com Percocet card, which may lug the cost down come $9.

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 Tylenol 3Percocet
Typically covered by insurance?YesYes
Typically covered by Medicare component D?YesYes
Standard dosage1 tablet computer (300 mg acetaminophen/30 mg codeine) every 4 hours as needed1 come 2 tablet computers (2.5 to 10 mg that oxycodone) every 4 come 6 hrs as needed
Typical Medicare copay$0–$1$0–$1
ubraintv-jp.com cost$8$9

Common side effects of Tylenol 3 vs. Percocet

The most usual side effects of Tylenol #3 and Percocet are drowsiness, lightheadedness, dizziness, and sedation. Both opioid drugs can also cause nausea, vomiting, dried mouth, and also headache. An additional common side result is opioid-induced constipation.

Serious side impacts may incorporate respiratory depression and hypersensitivity reactions. Consult clinical attention if you experience shallow breathing, serious rash, or ede of the face.

 Tylenol 3Percocet
Side effectApplicable?FrequencyApplicable?Frequency
DrowsinessYes*Yes*
LightheadednessYes*Yes*
DizzinessYes*Yes*
SedationYes*Yes*
Nausea/vomitingYes*Yes*
Dry mouthYes*Yes*
HeadacheYes*Yes*
ConstipationYes*Yes*

*not reported

Frequency is not based on data native a head-to-head trial. This might not it is in a finish list of adverse effects that deserve to occur. Please refer to your medical professional or healthcare provider to learn more.

Source: DailyMed (Tylenol 3), DailyMed (Percocet)

Drug interaction of Tylenol 3 vs. Percocet

Tylenol #3 and also Percocet are both metabolized, or processed, in the human body by liver enzymes. Certain drugs have the right to interfere with exactly how these enzyme work. For example, drugs the act as CYP3A4 inhibitors, such as erythromycin and also ketoconazole, have the right to increase opioid level in the body. This deserve to lead to serious side effects, such as respiratory depression.

Tylenol #3 and Percocet should be avoided or monitored while taking other drugs choose benzodiazepines, antipsychotics, antidepressants, and also anticonvulsants. This drugs have the right to have results on the central nervous system (CNS). Acquisition these medicine together deserve to increase the danger of side impacts such as drowsiness and dizziness.

The an unified use the opioids and also serotonergic drugs, like antidepressants, deserve to increase the danger of serotonin syndrome, a perhaps life-threatening condition.

Taking opioid analgesics with diuretics deserve to decrease the performance of the diuretics. Dosage might need to be adjusted and blood pressure may need to it is in monitored while taking both an opioid and diuretic.

Opioids have the right to increase the danger of urinary retention and constipation as soon as taken with anticholinergic drugs.

DrugDrug classTylenol 3Percocet
ErythromycinKetoconazoleRitonavirCYP3A4 inhibitorYesYes
RifampinCarbamazepinePhenytoinCYP3A4 inducerYesYes
ParoxetineBupropionQuinidineFluoxetineCYP2D6 inhibitorYesYes
LorazepamDiazepamAlprazolamClonazepamBenzodiazepineYesYes
ClozapineLurasidoneOlanzapineAntipsychoticYesYes
SertralineVenlafaxineMirtazapineTrazodoneSerotonergic drugYesYes
PhenelzineTranylcypromineLinezolidMonoamine oxidase inhibitor (MAOI)YesYes
MethocarbamolCyclobenzaprineCarisoprodolMuscle relaxantYesYes
BumetanideFurosemideHydrochlorothiazideDiureticYesYes
BenztropineAtropineAnticholinergic drugYesYes

Consult a healthcare skilled for other possible drug interactions

Warnings that Tylenol 3 vs. Percocet

Tylenol #3 and also Percocet are controlled substances v a high potential because that abuse, addiction, and misuse. However, due to the fact that of the potency, Percocet has a greater potential of abuse 보다 Tylenol #3. These opioid drugs should it is in taken under the indict of a medical care provider after a finish medical evaluation.

Abuse and dependence on these opioids deserve to increase the hazard of overdose. High doses of opioids have the right to lead to shallow breath (respiratory depression), confusion, ns of consciousness, and also even death. A prescribing doctor might recommend a naloxone reversal kit for certain patients at risk of one opioid overdose.

Opioid medications should be tapered, or discontinued gradually. Otherwise, there is a risk of withdrawal symptoms after permanent use. Withdrawal symptoms may include anxiety, fatigue, sweating, and also seizures.

Consult a medical care provider because that other feasible warnings and precautions linked with these prescription drugs.

Frequently request questions about Tylenol 3 vs. Percocet

What is Tylenol 3?

Tylenol #3, likewise known as the combination of acetaminophen and codeine, is one opioid pains reliever. It is FDA authorized for mild to moderate pain. Tylenol #3 is frequently prescribed after ~ an injury or dentist procedure. That is easily accessible in oral tablets with a toughness of 300 mg that acetaminophen and 30 mg the codeine.

What is Percocet?

Percocet is the brand name for the mix of acetaminophen and oxycodone. The is one opioid pains reliever FDA approved to law moderate to severe pain. It can be prescribed because that acute and also chronic pain. Percocet is available as an dental tablet.

Are Tylenol 3 and also Percocet the same?

Tylenol #3 and Percocet space both opioid painkillers, yet they space not the same. Although lock both save on computer acetaminophen, they contain different opioid ingredients; Tylenol #3 includes codeine when Percocet has oxycodone.

Is Tylenol 3 or Percocet better?

Percocet consists of a more powerful opioid ingredient than Tylenol #3. Compared to Tylenol #3, Percocet may be prescribed more often for significant pain. However, the performance of one of two people opioid medication eventually depends on the dosage used, the severity of pain being treated, and other pains relief therapies being used.

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Can I use Tylenol 3 or Percocet when pregnant?

Opioid painkillers are not typically recommended for use while pregnant. There is a potential for these opioids to reason birth defects. However, few studies have been conducted on the security of opioids throughout pregnancy. Opioid use during pregnancy have the right to lead to respiratory depression or withdrawal symptoms in the baby. Opioids have to only be used if the potential benefits outweigh the dangers during pregnancy.

Can I use Tylenol 3 or Percocet with alcohol?

It is not recommended to consume alcohol while taking Tylenol #3 or Percocet. Law so have the right to increase the hazard of side effects, such as drowsiness, dizziness, ns of coordination, and confusion. Drinking alcohol may also increase the threat of opioid overdose, coma, or even death in certain people, especially if there’s a history of abuse, addiction, and dependence on the drug.