In our latest question and answer, the pharmacist discusses just how lengthy Advil (ibuprofen) lasts in your device.

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Samantha asked

About exactly how lengthy does Advil remain in your system? I am simply looking to protect against drug interactions. Thanks!


Advil (ibuprofen) is a NSAID (non-steroidal anti-inflammatory drug) that is available over the counter (200 mg) and also as a prescription (400 mg, 600 mg and also 800 mg) for the treatment of mild to modeprice pain and associated problems.

For a lot of people, it will certainly be completely eliminated from your mechanism within 12-24 hrs (with particular factors such as age and also liver function affecting this time frame).

Ibuprofen Characteristics

Ibuprofen is the active ingredient in Advil and Motrin. it is also available generically simply as "ibuprofen".

The half-life of a given drug is normally a pretty trustworthy indicator of just how lengthy it lasts in our device. The "half-life" refers to the time it takes to metabolize 50% of a drug. In a lot of instances, a drug is completely eliminated within 5 to 6 half-resides (1).

The half-life of ibuprofen is around 2 to 4 hours (2), which means that it will certainly be eliminated within 12-24 hrs for a lot of individuals.

Factors That Influence Advil Elimination

As stated over, tbelow are a couple of components that influence ibuprofen half-life:

AgeLiver functionAge

Ibuprofen is metabolized and got rid of fasterin pediatric patients compared to adults. The prescribing indevelopment for one ibuprofen product (Caldolor) reports a half-life of about 1.5 to 1.8 hrs in youngsters and also teenagers (3). This implies that it will be completely eliminated in around 12 hrs for this age group.

Liver Function

The half-life of ibuprofen is substantially prolonged in individuals with liver disability with many research studies particularly referring cirrosis. It has been reported that in patients with cirrosis, the half-life ca boost by over 50% (4).

Further Information

It must be listed that while ibuprofen lastsin your mechanism for 12-24 hours for the majority of, the actual duration of activity is much shorter.

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After taking a dose by mouth, optimal concentrations of the drug are got to (on average) in (4):

120 minutes for tablets 62 minutes for chewable tablets47 minutes for liquids (e.g. suspensions)

The typical duration of actionis 4 to 6 hrs for the majority of people. For this factor, ibuprofen is recommended to be dosed eextremely 4 to 6 hours.