Medically reviewed by Mohamed Jalloh — created by university of Illinois — updated on February 1, 2019


Excedrin Migraine is an over-the-counter pain relief medication. It’s mostly used to treat pain due to migraine headaches. This is what you need to know around how Excedrin Migraine works and also how to use it safely.

Learn the difference: Migraine vs. Headache »

Excedrin Migraine is a mix medication. It has three different drugs: acetaminophen, aspirin, and caffeine. This drugs work in different ways to aid relieve her migraine pain.

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Acetaminophen is a pain reliever and fever reducer. Just how it works precisely is no known. Us do know that the works mostly in the central nervous system, which consists of the brain and spinal cord. Acetaminophen increases the quantity of pain her body deserve to tolerate by reduce the quantity of prostaglandins it produces. A prostaglandin is a substance that’s linked with pain.


Aspirin is a nonsteroidal anti-inflammatory drug (NSAID). The reduces pain and also inflammation, which contains swelling and irritation. Aspirin also reduces the lot of prostaglandins the body produces, yet differently from just how acetaminophen does.


Caffeine is not a pains reliever. Rather, it’s a vasoconstrictor. That way it renders blood ship narrower. In Excedrin Migraine, caffeine works to narrow blood vessels in your brain. This reduce the quantity of blood the can circulation through the blood vessels at one time. This action helps combat headaches, which happen when blood vessels widen.

Caffeine additionally helps relax a headache if it’s led to by caffeine withdrawal.

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Excedrin Migraine comes as a caplet you take it by mouth. Each caplet includes 250 mg acetaminophen, 250 mg aspirin, and also 65 mg caffeine. The recommended dosage is detailed below by age. You can additionally find this dosage information on the product’s packaging.

Adults 18 years and older

Take two caplets through a glass the water. The maximum dosage is 2 caplets in any 24-hour period.

Children and also teens younger than 18 year

Talk v your child’s doctor before giving your son Excedrin Migraine.

Because it has aspirin, you must be very careful when offering Excedrin Migraine to children and teens. This is since aspirin is attached with Reye’s syndrome, a rare yet serious illness. Never ever give products that save on computer aspirin to a child younger than 12 years. And also don’t provide aspirin come a teenager if they’re recovering indigenous a viral an illness such together chicken pox or the flu.

Learn more: dealing with migraines and severe migraines »

Each the the three drugs in Excedrin Migraine can cause some side effects. Some effects may walk away together your human body becomes offered to the medication. Yet if any kind of of the typical side effects cause problems for you or don’t walk away, call your doctor. And if friend have any of the serious side effects, contact your medical professional or 9-1-1 right away.

Common side effects

The more common side effects of Excedrin Migraine can be resulted in by the caffeine that’s in it. This side impacts can include:

nervousness emotion irritablesleeping troublerapid heartbeat

Serious next effects

The serious side effects of Excedrin Migraine have the right to be brought about by the acetaminophen and also aspirin that contains. These side effects can include:

allergic reaction, through symptoms such as:trouble breathingitchy, red blistersrashbleeding in the stomach, v symptoms such as:bloody or black and tarry stoolsvomiting bloodupset stomach the does not improve quickly

If you take medication in enhancement to Excedrin Migraine, it may cause drug interactions. Interactions deserve to increase or to decrease the impact of Excedrin Migraine or your various other medications. Castle can additionally increase your threat of side effects.

Be sure to talk through your doctor prior to taking Excedrin Migraine if girlfriend use any type of of the adhering to medications:

blood thinners such as warfarin, rivaroxaban, and also apixabannonsteroidal anti-inflammatory drugs (NSAIDs) such together ibuprofen, naproxen, 81-mg or 325-mg aspirin, enteric-coated aspirin, and celecoxibgout drugs such as probenacidantiseizure drugs such as phenytoin and also valproic acidmedications offered to treat coagulation such together alteplase and reteplaseangiotensin-converting enzyme (ACE) inhibitors such as lisinopril, enalapril, and ramiprilantacids together as sodium bicarbonate and magnesium hydroxidepsychiatric medicine such together furazolidone, procarbazine, and selegiline antidepressants such together sertraline and venlafaxineantiplatelet medicine such as clopidogrel, prasugrel, and ticagrelordiuretics such together furosemide and also hydrochlorothiazideherbal medications such together echinacea, garlic, ginger, and gingkoclozapinemethotrexate

Excedrin Migraine is safe for many people, yet it must be supplied carefully. Some people should prevent it completely. The complying with warnings can help keep you safe.

Conditions the concern

If you have any kind of of the complying with conditions, questioning your physician if it’s for sure for friend to use Excedrin Migraine. This medication may make the following problems worse:

liver diseasestomach problems, such as heartburn, stomach ulcers, or stomach bleedinghigh blood pressurekidney diseaseasthmathyroid disease

Liver damage

Acetaminophen, one of the medicine in Excedrin Migraine, can cause severe liver damage. You have actually a higher risk of liver damages if you take it Excedrin Migraine and also do any type of of the following:

use much more than the maximum everyday amount (two caplets in 24 hours) take it other commodities that contain acetaminophenconsume three or much more alcoholic drinks per day

Stomach bleeding

Aspirin can cause severe stomach bleeding. You have actually a greater risk the stomach bleeding if you:

are older than 60 yearshave a history of stomach ulcer or bleeding additionally take a blood thinner or steroid such as prednisone, methylprednisolone, or hydrocortisone likewise take various other drugs that contain NSAIDs, such together aspirin, ibuprofen, or naproxen consume 3 or much more alcoholic drink per day take it this product for longer than your medical professional recommends

In instance of overdose Be certain to follow dosage instructions very closely to avoid the risk of overdose. Symptoms of one overdose that Excedrin Migraine have the right to include:

pain in your abdomenindigestionheartburnnauseavomitingjaundice (yellowing of your skin or the whites of her eyes)

If you pregnant or breastfeeding, talk v your doctor prior to taking Excedrin Migraine.


Ask your medical professional if it’s for sure for friend to take Excedrin Migraine throughout the an initial two trimesters of your pregnancy.

You need to not usage Excedrin Migraine throughout the critical trimester (three months) that pregnancy, together it may harm your pregnancy. This is since Excedrin Migraine consists of aspirin. Using regular-strength aspirin frequently in the third trimester can reason a serious birth defect of her baby’s heart.


Be sure to talk v your doctor before using this drug while breastfeeding. Acetaminophen, one of the active ingredients in Excedrin Migraine, is safe for usage while breastfeeding. However, the aspirin in Excedrin Migraine can pass right into breast milk. Regular-strength aspirin, which is the kind contained in Excedrin Migraine, may reason rash, bleeding, and also other troubles in a child who is breastfed.

The info in this short article can help you take it Excedrin Migraine safely. Below are a few things to save in mind:

Carefully review the brand of various other pain relievers you’re taking before using Excedrin Migraine. Taking other products that contain the same energetic ingredients as Excedrin Migraine can lead to overdose. Border the quantity of caffeinated drinks or foods items you consume. This medication has caffeine, and also eating or drinking too much caffeine deserve to make your heart beat much faster or do you feeling jittery.If you have symptoms that an allergic reaction to Excedrin Migraine or have actually black, tarry stools, speak to 9-1-1 appropriate away.

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If girlfriend have more questions around Excedrin Migraine, talk through your physician or pharmacist.