In our latest question and answer, the pharmacist discusses whether or not it is safe to take Tylenol PM via alprazolam (Xanax).

You are watching: Can i take tylenol with xanax


Paul asked

Can you take Tylenol PM and alprazolam together?


Tright here are no significant drug interactions in between Tylenol PM and alprazolam and they can be taken together in specific cases. However before, conexisting use of Tylenol PM and alprazolam need to be done through caution, dueto both medicines being CNS (central nervous system) depressants.

Specifically, we are pertained to around the diphenhydramine consisted of in Tylenol PM and alprazolam. As mentioned over, both are CNS depressants and can reason additive sedation when used together. Radepend, the combination might reason confusion and also respiratory depression.

In the majority of situations, Tylenol PM and alprazolam need to be dosed apart from one an additional to avoid the additive sedative impacts. For a lot of people, it would certainly be considered safe to take alprazolam during the day and also take Tylenol PM only at night as a sleep aide.

For those who have been on a constant dose of alprazolam for extfinished durations of time, it might be okay to take it via Tylenol PM at the same time, however you must soptimal via your doctor prior to doing so.

Tylenol PM

Tylenol PM is a mix product that contains:

Acetaminophen (brand name is Tylenol)Diphenhydramine (the common brand name is Benadryl)

Tylenol PM is typically used as a pain reliever and/or sleep help. Acetaminophen is a centrally acting analgesic and antipyretic that is reliable at relieving pain and also reducing fever before.

Diphenhydramine is a first generation antihistamine. Diphenhydramine deserve to be supplied for several indications including:

Allergies or allergic reactionCold/flu symptomsSleep aidMotion sickness

Side effects of diphenhydramine includedrowsiness, confusion, dizziness, and dry mouth.


Alprazolam (brand name Xanax) is a benzodiazepine that is generally used to treat tension. Alprazolam is also a CNS depressant and also deserve to have actually side results consisting of drowsiness/sedation, confusion, and also dizziness.

See more: How Did You Fair Or Fare Vs, Difference Between Fair & Fare With Examples


Tbelow are no major drug interactions between Tylenol PM and alprazolam; however, alprazolam and diphenhydramine (from Tylenol PM) are both CNS depressants.

Concurrent usage may boost the chance of side results, such as enhanced drowsiness, sedation, or confusion. These agents must be offered in combicountry via caution.