In our latest question and answer, the pharmacist discusses whether or no it is for sure to take it Tylenol PM v alprazolam (Xanax).

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Paul asked

Can you take it Tylenol PM and also alprazolam together?


There space no major drug interactions between Tylenol PM and alprazolam and they can be taken with each other in particular situations. However, concurrent usage of Tylenol PM and also alprazolam must be done through caution, dueto both medicines being CNS (central concerned system) depressants.

Specifically, we are concerned around the diphenhydramine had in Tylenol PM and alprazolam. As pointed out above, both room CNS depressants and can cause additive sedation when provided together. Rarely, the mix could reason confusion and respiratory depression.

In many cases, Tylenol PM and also alprazolam must be dosed except one another to protect against the additive sedative effects. For many individuals, it would certainly be thought about safe to take it alprazolam during the day and take Tylenol PM only at night together a sleep aide.

For those who have actually been on a consistent dose that alprazolam for expanded periods the time, it may be it s okay to take it with Tylenol PM in ~ the same time, but you should speak with your doctor before doing so.

Tylenol PM

Tylenol pm is a combination product that contains:

Acetaminophen (brand surname is Tylenol)Diphenhydramine (the typical brand name is Benadryl)

Tylenol afternoon is typically used as a pains reliever and/or sleep aid. Paracetamol is a centrally acting analgesic and antipyretic that is effective at relieving pain and also reducing fever.

Diphenhydramine is a an initial generation antihistamine. Diphenhydramine can be provided for number of indications including:

Allergies or allergic reactionCold/flu symptomsSleep aidMotion sickness

Side results of diphenhydramine includedrowsiness, confusion, dizziness, and also dry mouth.


Alprazolam (brand name Xanax) is a benzodiazepine that is typically used come treat anxiety. Alprazolam is also a CNS depressant and can have actually side effects including drowsiness/sedation, confusion, and also dizziness.

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There are no major drug interactions between Tylenol PM and also alprazolam; however, alprazolam and also diphenhydramine (from Tylenol PM) space both CNS depressants.

Concurrent usage may boost the opportunity of next effects, such as boosted drowsiness, sedation, or confusion. This agents have to be used in mix with caution.